Identification of natural products with interesting, often novel, structures and useful biological properties that may lead to medicinal agents for treatment of cancer, cardiovascular disorders and infectious diseases.

Design, synthesis, and evaluation of small molecule libraries. A particular emphasis is placed on therapeutically important receptor or enzyme classes that require the development of new combinatorial design strategies and/or synthesis chemistry.

Chemistry of natural products. Chemical carcinogenesis. Mechanisms of biologically important reactions. Synthesis of farmacologically active compounds. Hemisynthesis. Computational organic chemistry. Development of new synthetic methods and reagents for organic synthesis.

Total Synthesis.

Biomimetic and total synthesis, and beta-lactam biosynthesis.

Synthesis of biologicaly active and structurally complex natural products and the development of new reaction methodology.

Development of new chemical and enzymatic strategies and methods for the synthesis of biologically active compounds and designed molecules as mechanistic probes and inhibitors of carbohydrate-mediated biological recognitions, sequence-specific RNA recognition, and enzymatic reactions.

Total synthesis.

Flourine Chemistry, Fluoroolefin Peptidomimetics, Precursor Design for the Chemical Vapor Deposition of Metals, Catalyst Systems for the Syndiotactic Polymerization of Styrene, Pyrazinamide, Analogs and the Mechanism of Action of an Antituberculous Agent.

New catalytic organic and organometallic transformations, their mechanism studies and their ultimate application to the total synthesis of architecturally challenging and biologically important natural products.